May stress affect the brain?
Because of the high developing speed of the world, stress becomes an inevitable part in our normal life. In fact, 2 out of 3 adults report experiencing some level of stress in their everyday lives and over 1 out of 3 teenagers need to face fierce competence with great stress. With lots of stress may seriously affect our physical and mental well-being, it would cause negative effects of our immune system and the brain ability. Moreover, it may inhibit the ability to form memories and loss part of the cognitive ability. In order to maintain a healthy state and a clear mind, the properly relaxation and stable guts microbiota are the keys point.
 
The second brain – Your gut.
The intestines are often referred to as our body’s second brain because there are hundreds of billion neurons connecting the brain to the intestines and secreting various hormones or neurotransmitter. Many studies have shown that the gut-brain connection is bidirectional and the routes of communication between the microbiota and brain are slowly being unraveled. The imbalance gut microbiota can cause immune system problems, mental perturbations and endocrine unbalance through different pathways such as the autonomic, enteric nervous system and the endocrine system (1). That is the brain communicating with the intestines microbiota, or more scientifically known as the Gut-Brain Axis Source.
 
New research and future trends of probiotics.
Through the Gut-Brain Axis, your guts microbiota can also talk to your brain. Recent researches show that consuming probiotics may help improve your immune system and the brain health. The animal experimentation published in Translational Psychiatry from Xiao et al. (2020) indicates that the group with a multi-strain probiotics blend (BL986, LA1063, LF26, LH43, LPC12, LRH10, ST30) shows the gut microbiota composition was reshaped and the richness was significantly increased. Moreover, it shows a decrease concentration of inflammatory cytokines and the upregulate of intestinal protein expression (3). Ni et al. (2019) found that Lactobacillus casei LC122 and Bifidobacterium longum BL986 can also balance the gut microbiota, upregulation of neurodegenerative, and neurotrophic factors expressions which can promote the cognition of mice in the animal model (2). Consequently, with probiotics supplement can not only regulate the gut microbiota but also maintain the healthy state of brain.
 
A healthier gut, a healthier brain.
Probiotics are the top seller in the U.S. mainstream and natural supplement market, racking up sales of $759 million and $126.9 million, respectively, last year based on SPINS report on the 52 weeks ending November 29, 2020. Over the past years, there has been substantial research in the field of probiotics which specifically into the different mechanism of probiotic action within the host. The most important thing is that the probiotics category will continue to grow and infiltrate multiple product categories in a variety of delivery formats to satisfy the needs of a large cross-section of consumers, providing options for everyone. Probiotics could cause positive effect on a clear and active mind by maintaining the gut microbiota with the Gut-Brain Axis. Supplementation of probiotics continuously may not only support a healthier gut, but a healthier brain.
 
Reference:
[1] Morais, L. H., Schreiber, H. L., 4th, & Mazmanian, S. K. (2020). The gut microbiota-brain axis in behaviour and brain disorders. Nature reviews. Microbiology, 10.1038/s41579-020-00460-0. Advance online publication.
[2] Ni Y, Yang X, Zheng L, et al. Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota. Mol Nutr Food Res. 2019;63(22): e1900603.
[3] Xiao, J., Wang, T., Xu, Y., Gu, X., Li, D., Niu, K., Wang, T., Zhao, J., Zhou, R., & Wang, H. L. (2020). Long-term probiotic intervention mitigates memory dysfunction through a novel H3K27me3-based mechanism in lead-exposed rats. Translational psychiatry, 10(1), 25.

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