Press Release


TWK10® muscle probiotics: A new stage of opportunity in healthy aging

TWK10® muscle probiotics: A new stage of opportunity in healthy aging

Living longer: Silver generation, golden opportunity!
Thanks to the advancement of medical technology and better living conditions, we all live longer and resulting in accelerated aging of the population. In fact, the United Nations estimated that by 2050, the population over the age of 65 will reach 1.5 billion, and the elderly population will account for 22% of the global population[9]. However, increased life expectancy does not necessarily mean improved healthy life expectancy, but it comes with various aging-related health issues.

Healthy aging has become a major nutraceutical trend as the global senior population is growing. The study suggests that senior population are actively looking into the proactive management of their health putting a great emphasis on prevention not merely curing the disease. They are seeking solutions to live better as they age and they see taking supplements as one possible option to improve the sign of aging, as a result, clinically validated high quality supplements are in high demand. Research suggests that the older adults’ health supplements market is projected to reach US$ 265 Billion by 2032 with a CAGR of 6% from 2021 to 2032[2].
Skeletal muscle: An important indicator of "Aging"
Among aging-associated disorders, the most common issue is that muscle mass and strength gradually decline during the aging process [4].Skeletal muscle is the most important organ affecting human metabolism and energy reservation, accounting for more than 40% of body weight [5]. The “mass, quality and strength” of skeletal muscle begin to lose at high speed after mid-life age, decline at a rate of between 1% and 2% per year from the age of 50, 1.5% per year from the age of 50–60, and 3% per year thereafter, thereby significantly increasing the risk of falls, cognitive impairment, morbidity, disability, and mortality[1][7]. This degenerative loss accompanies aging and reduced functional activity is known as "sarcopenia"[7]. As the population ages, muscle health has become an ever-increasing concern and is expected to be a significant focus for future supplement development.
New probiotics concept: gut-muscle axis
Studies have found that the gut microbiota affects the host's muscle mass and function by regulating the systemic immune system, anabolism, insulin sensitivity, and energy production, termed the "gut-muscle axis"[3]. During the aging process, the diversity of gut microbes gradually declines, which disrupts the gut microbiome balance, promotes systemic inflammation, and causes muscle cell damage, resulting in decreased muscle mass and muscle strength[3]. Probiotics supplementation seems to be one of the most effective ways to increase and change the proportion and distribution of gut microbiota[6].  
Clinically validated solution for muscle loss
A clinical study published in the Journal of Microorganisms in 2021 found that after taking TWK10® for 18 consecutive weeks, 42 elderly subjects aged 55 - 85 with mild fragility were greatly shown to improve muscle mass, grip strength and lower limb strength. Furthermore, the speed of walking and the stability of standing were also significantly improved [6].

Based on the remarkable clinical evidence, vegan and naturally sourced TWK10®  is a promising ingredient for healthy aging supplements to enhance muscle strength and reduce physical fragility and the risk of sarcopenia. With clinically validated efficacy and a flexible delivery format, brands may seize the golden opportunity by helping the silver generation stay healthy and happy as they age.
[1] Dawson, A., & Dennison, E. (2016). Maturitas, 93, 13-17.
[2] Future Market Insights. (2021). Older Adults Health Supplements Market Overview (2022-2032). Future Market Insights. Retrieved July 13, 2022, from
[3]Giron, M., et al. (2022). Journal of cachexia, sarcopenia and muscle, 13(3), 1460–1476.
[4] Keller, K., & Engelhardt, M. (2013). Muscles, ligaments and tendons journal, 3(4), 346.
[5] Kim, K. M., Jang, H. C., & Lim, S. (2016). The Korean journal of internal medicine, 31(4), 643–650.
[6] Lee, M. C., et al. (2021). Microorganisms, 9(7), 1466.
[7] Larsson, L., et al. (2019). Physiological reviews, 99(1), 427–511.World Population Ageing 2019: Highlights. the United Nations.
[8] World Population Ageing 2019: Highlights. the United Nations.

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